Principal Investigator Stephen Bell
Co-investigators Christopher Burge , Tania Baker , David Bartel , Laurie Ann Boyer , Iain Cheeseman , Catherine Drennan , Frank Gertler , Barbara Imperiali , Amy Keating , Jonathan King , Monty Krieger , Michael Laub , Harvey Lodish , Adam Martin , Uttam RajBhandary , Robert Sauer , Thomas Schwartz , Phillip Sharp , Frank Solomon , JoAnne Stubbe , Matthew Vander Heiden , Graham Walker
Project Website http://biology.mit.edu/research/biochemistry_biophysics
Research in biochemistry and biophysics is focused on numerous processes central to understanding life. Several groups use biochemical and structural approaches to address the basic principles governing protein folding, function and biological recognition. Using in vitro approaches, the central steps in biological information transfer are being analyzed, from maintenance of the genome to protein synthesis, sorting and processing.
Among the processes being investigated: DNA replication, recombination and repair; transcription and gene regulation, RNA splicing; protein synthesis; chromosome segregation; cell motility and the cytoskeleton; the structural basis of protein-DNA and protein-protein recognition; protein folding, quality control and design; catalytic RNA; signal transduction and central nervous system function.