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Prof. Frank Solomon
Professor of Biology
Primary DLC
Department of Biology
MIT Room:
76-561C
(617) 253-3026
solomon@mit.edu
Areas of Interest and Expertise
Cellular Specification of Detailed Shape and Movement
Cell Biology and Biochemistry
Cytoskeletal Organization and Function In Vivo, Using Biochemistry, Genetics, Molecular Biology, and Microscopy
Biochemistry and Biophysics
Cancer Biology
Cell Mobility
Neurobiology: Mechanisms of Neurite Outgrowth
Research Summary
Microtubules are essential for the establishment and maintenance of cell shape and organization of the cytoplasm, and for motile activities such as chromosome segregation. Our lab studies how cells regulate assembly and functional interactions of microtubules. Genetic and molecular approaches to these problems have identified novel steps in microtubule morphogenesis. These approaches have also identified detailed interactions between microtubule components and elements of other important cellular functions, including cell cycle control, protein folding and gene expression.
Recent Work
Projects
July 12, 2006
Department of Biology
Undimerized Beta-Tubulin is Toxic
Principal Investigator
Frank Solomon
July 12, 2006
Department of Biology
Rbl2p Protects Cells from Excess Beta-Tubulin
Principal Investigator
Frank Solomon
July 12, 2006
Department of Biology
A New Step in Microtubule Morphogenesis
Principal Investigator
Frank Solomon
July 12, 2006
Department of Biology
An Alpha-Tubulin Mutant Affects Heterodimer Stability
Principal Investigator
Frank Solomon
July 12, 2006
Department of Biology
An Alpha-Tubulin Mutant Interacts with Mitotic Checkpoint Genes
Principal Investigator
Frank Solomon
July 12, 1999
Department of Biology
Quantitative Regulation of Tubulin Expression
Principal Investigator
Frank Solomon
July 12, 1999
Department of Biology
Promoting Formation of the Heterodimer
Principal Investigator
Frank Solomon
Related Faculty
Prof. Robert T Sauer
Salvador E Luria Professor of Biology
Dr. Tomas Pluskal
Postdoctoral Associate
Kevin Ohashi
Research Affiliate