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Prof. Stephen P Bell
Uncas (1923) and Helen Whitaker Professor of Biology
Howard Hughes Medical Institute (HHMI) Investigator
Primary DLC
Department of Biology
MIT Room:
68-630
(617) 253-2054
spbell@mit.edu
http://biology.mit.edu/people/stephen_bell
Areas of Interest and Expertise
Mechanisms Regulating the Duplication and Expression of the Eukaryotic Genome
Origin Recognition Protein (ORC) and the Initiation of DNA Synthesis from Yeast Origins of Replication
Relationship Between DNA Replication and Transcriptional Control
Biochemistry and Biophysics
Cell Biology
Genetics
Research Summary
Professor Bell focuses on the events that occur at the starting points of chromosome duplication. These DNA sequences -- called “origins of replication” -- are found at multiple sites on each eukaryotic chromosome and direct the assembly of replisomes, which replicate the DNA on both sides of the origin. We study this assembly process to understand how chromosomes are replicated, and how these events are regulated during the cell cycle to ensure genome maintenance.
Recent Work
Projects
June 1, 2020
Department of Biology
Bell Lab
Principal Investigator
Stephen Bell
December 2, 2011
Department of Biology
Assembly of DNA Replication Complexes
Principal Investigator
Stephen Bell
December 2, 2011
Department of Biology
Prevention of Re-Replication
Principal Investigator
Stephen Bell
December 1, 2011
Department of Biology
Biochemistry and Biophysics Research
Principal Investigator
Stephen Bell
August 26, 2009
Department of Biology
Initiation of DNA Replication of Yeast Chromosomes
Principal Investigator
Stephen Bell
December 20, 2006
Department of Biology
Chromosome Duplication in Drosophila melanogaster
Principal Investigator
Stephen Bell
December 20, 2006
Department of Biology
DNA Replication in S. cerevisiae
Principal Investigator
Stephen Bell
December 20, 2006
Department of Biology
Origin Selection and Activation
Principal Investigator
Stephen Bell
Related Faculty
Prof. Susumu Tonegawa
Picower Professor of Biology and Neuroscience
Prof. Yadira M Soto-Feliciano
Howard S (1953) and Linda B Stern Career Development Assistant Professor of Biology
Dr. T G Sambandan
Research Affiliate