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Prof. Stephen P Bell
Uncas (1923) and Helen Whitaker Professor of Biology
Howard Hughes Medical Institute (HHMI) Investigator
Primary DLC
Department of Biology
MIT Room:
68-630
(617) 253-2054
spbell@mit.edu
http://biology.mit.edu/people/stephen_bell
Areas of Interest and Expertise
Mechanisms Regulating the Duplication and Expression of the Eukaryotic Genome
Origin Recognition Protein (ORC) and the Initiation of DNA Synthesis from Yeast Origins of Replication
Relationship Between DNA Replication and Transcriptional Control
Biochemistry and Biophysics
Cell Biology
Genetics
Research Summary
Professor Bell focuses on the events that occur at the starting points of chromosome duplication. These DNA sequences -- called “origins of replication” -- are found at multiple sites on each eukaryotic chromosome and direct the assembly of replisomes, which replicate the DNA on both sides of the origin. We study this assembly process to understand how chromosomes are replicated, and how these events are regulated during the cell cycle to ensure genome maintenance.
Recent Work
Projects
June 1, 2020
Department of Biology
Bell Lab
Principal Investigator
Stephen Bell
Related Faculty
Prof. Omer Yilmaz
Associate Professor of Biology
Prof. Uttam L RajBhandary
Lester Wolfe Emeritus Professor of Molecular Biology, Emeritus
Prof. Yadira M Soto-Feliciano
Howard S (1953) and Linda B Stern Career Development Assistant Professor of Biology