Can data series from a broad patient population be relevant and reliable tools in predicting individual outcomes when compared to personal wellness sensor data? Or, simply put from a patient perspective, “Can what happen to them, happen to me?” Retrieving and making use of “like-me” signal data based on similarity presents challenges far beyond digital marketing’s effectiveness in making targeted book and movie recommendations. By investigating and understanding those unique challenges, our research group has developed an approach based upon locality sensitive hashing (LSH). We will provide an update on our progress towards adapting LSH for fast and accurate Signal Like-Me capability.