Immune homeostasis requires constant collaboration between a diverse and dynamic set of cell types. Within our immune tissues, distinct cellular subsets must work together to defend against pathogenic threats, maintain tolerance, and establish memory. While surveying multiple healthy individuals enables exploration of potential ensemble immune solutions, contrasts against outliers of health and disease can reveal deviations that underscore diagnostic, therapeutic, and prophylactic features of enhanced function or dysfunction. Here, I will discuss how we can leverage single-cell genomic approaches – and, in particular, single-cell RNA-Seq – to explore the extensive functional diversity among immune cells within and across individuals, and uncover, from the bottom-up, distinct cell types and states associated with improved immunity. Moreover, I will discuss emerging experimental and computational strategies for altering ensemble cellular responses through targeted intra- or extracellular induction of these preferred types and states.
Hossein Rahnama
Join industry leaders at our highly anticipated MIT Houston conference, Future-Proofing Your Operations, and gain the insights needed to navigate the dramatic changes driven by global economic forces, emerging technologies, and evolving government policies. This event will explore the transformative power of artificial intelligence (AI), essential workforce development strategies, groundbreaking advancements in manufacturing, shifting international trade patterns, and the impact of recent U.S. legislation on industrial policy.
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This webinar will discuss insights that are important to build resilient and efficient supply chains under uncertain environments. Speakers will elaborate on how understanding business characteristics, and using quantitative approaches may help mapping leverage points, understanding challenges and gaining flexibility in supply chains. Attendees will learn innovative strategies to support their decision-making processes to create proactive, adaptable business models through the use of data analytics while reducing costs and expanding their market share without compromising their long-term financial sustainability.
Alex Shalek, Director of the Institute for Medical Engineering and Science (IMES), examines how chronic environmental and metabolic stress alters cell behavior and drives tissue dysfunction. The talk highlights cutting-edge single-cell and spatial multi-omics research revealing how prolonged stress reshapes liver cell identity, promotes cancer-associated pathways, and predicts poorer health outcomes. It also introduces new computational and high-throughput screening platforms designed to identify regulators of cellular balance and accelerate discovery of strategies that strengthen tissue health and resilience.
Everactive Munehiko Sato CTO, Mui Lab Lifeng Wang Co-founder & CEO, Eion Technologies Jifei Ou Founder & CEO, OPT Industries Bobby Brooke Herrera Co-founder & Chief Science Officer, E25Bio S. Roy Kimura Founder & CEO, Modulus Discovery Pablo Lapuerta Founder & CEO , 4M Therapeutics