Principal Investigator Linda Griffith
Co-investigators Barbara Imperiali , M Kaashoek , Paula Hammond , Douglas Lauffenburger , Moungi Bawendi , Yoel Fink , Paul Blainey , W David Lee , Katharina Ribbeck , Jongyoon Han , Anette Hosoi , John Guttag , Frank Gertler , Alexander Slocum
One are of study is why susceptibility of HIV infection in women is increased in association with immune/inflammatory system responses to other pathogens present. Samples from clinical patients in South Africa are analyzed with respect to cellular and molecular components, using computational systems biology methods, to elucidate how resistance to HIV is compromised in women suffering from these co-morbid infectious diseases. Another area of study is how infectious agents are transported across mucus barriers and how mucins act as antiviral agents, for example by binding to sperm.