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Back to Faculty/Researchers
Prof. Bruce Tidor
Professor of Biological Engineering and Computer Science
Vice Provost for International Activities
Primary DLC
Department of Biological Engineering
MIT Room:
32-212
(617) 253-7258
tidor@mit.edu
https://be.mit.edu/directory/bruce-tidor
Assistant
Nira Manokharan
(617) 253-5977
nira@csail.mit.edu
Areas of Interest and Expertise
Biomolecular Engineering
Biophysics
Computational Modeling
Drug Delivery
Macromolecular Biochemistry
Omics
Pharmacology
Systems Biology
Research Summary
Professor Tidor completed his Bachelor’s degree in Chemistry and Physics at Harvard College. After a Master of Science degree at the University of Oxford, UK as a Marshall Scholar, he returned to his Alma Mater at Harvard for his doctoral studies in Biophysics. Tidor spent four years as a Whitehead Fellow at the Whitehead Institute for Biomedical Research. He joined MIT as Assistant Professor of Chemistry in 1994, became Associate Professor of Biological Engineering and Computer Science in 2001, and Professor of Biological Engineering and Computer Science in 2005.
Research is focused on the analysis of complex biological systems at both the molecular level and the systems level. Our molecular work concentrates on the structure and properties of proteins, nucleic acids, and their complexes. Investigations probe the sources of stability and specificity that drive folding and binding events of macromolecules. Studies are aimed at dissecting the interactions responsible for the specific structure of folded proteins and the binding geometry of molecular complexes. The roles played by salt bridges, hydrogen bonds, side-chain packing, rotameric states, solvation, and the hydrophobic effect in native biomolecules are being explored, and strategies for re-casting these roles through structure-based molecular design are being developed. Work at the systems level involves the construction and analysis of correlated patterns of gene expression and their relation to biochemical regulatory networks and signal transduction pathways in cells. Much of this work is motivated by the enormous advances in genome science and in the availability of parallel arrays of gene expression data. The methods of theoretical and computational biophysics and approaches from artificial intelligence, applied mathematics, and chemical engineering play key roles in our work.
Recent Work
Projects
January 9, 2012
Department of Biological Engineering
Computational Design of Inhibotor Specificity
Principal Investigator
Bruce Tidor
September 26, 2008
Department of Biological Engineering
Using Optimal Time Varying Inputs to Probe Biochemical Signaling Networks
Principal Investigator
Bruce Tidor
October 18, 2007
Department of Biological Engineering
Information Theoretic Approaches to Identifying Informative Subsets of Biological Data
Principal Investigator
Bruce Tidor
October 18, 2007
Department of Biological Engineering
Parameterizing Biological Networks
Principal Investigator
Bruce Tidor
October 9, 2007
Department of Biological Engineering
MIT-Portugal Portugal (MPP): Engineering Design and Advanced Manufacturing (EDAM)
Principal Investigator
Bruce Tidor
June 21, 2007
Department of Biological Engineering
Decoding the Mechanism of Oscillations in Feedback-Connected Biological Networks
Principal Investigator
Bruce Tidor
June 21, 2007
Department of Biological Engineering
Biomolecular Transduction of Mechanical Signals: Simulation Study of Force-Modulated Protein Activity
Principal Investigator
Bruce Tidor
February 21, 2007
Department of Biological Engineering
Creation of a Biological Calcium Sensor by the Rational Redesign of Calmodulin
Principal Investigator
Bruce Tidor
February 21, 2007
Department of Biological Engineering
Molecular Design of Drug Resistance Resistant Inhibitors
Principal Investigator
Bruce Tidor
December 22, 2006
Department of Biological Engineering
DNA Repair
Principal Investigator
Bruce Tidor
October 11, 2006
Department of Biological Engineering
MIT-Portugal Program (MPP)
Principal Investigator
Bruce Tidor
December 21, 2005
Department of Biological Engineering
Understanding Oscillatory Biological Systems Using Dynamic Optimization Techniques
Principal Investigator
Bruce Tidor
December 15, 2005
Department of Biological Engineering
Biological Networks Design Principle: Discovery Through Dynamic Optimization
Principal Investigator
Bruce Tidor
September 12, 2004
Department of Biological Engineering
Antibody Affinity Maturation Using Computational Protein Design
Principal Investigator
Bruce Tidor
April 12, 2003
Department of Biological Engineering
Computational Analysis and Prediction of Phosphopeptide Binding Sites
Principal Investigator
Bruce Tidor
May 6, 1998
Department of Biological Engineering
Tidor Lab: Analysis of Biological Systems
Principal Investigator
Bruce Tidor
Related Faculty
Catherine Communal,
Technical Program Manager
Dr. Sean A Clarke
Principal Lecturer
Dr. Ujjal Sarkar
Research Affiliate