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Prof. Patrick S Doyle
Robert T Haslam (1911) Professor of Chemical Engineering
Graduate Officer, Chemical Engineering
Primary DLC
Department of Chemical Engineering
MIT Room:
E17-504F
(617) 253-4534
pdoyle@mit.edu
https://doylegroup.mit.edu/
Areas of Interest and Expertise
Microfluidics
Single Molecule DNA Dynamics
Polymer Physics
Transport Phenomena
Rheology
Colloids
Research Summary
Professor Doyle's research focuses on understanding the dynamics of single polymers and biomolecules under forces and fields. A second part of the research concerns the synthesis and studies (fundamental and applied) of microparticles in microfluidic devices. Both experimental and computational approaches are utilized in the research in order to understand fundamental issues in a wide variety of applications ranging from lab-on-chip separations to polymer rheology. We profit from interdisciplinary collaboration with biologists, physicists and mechanical engineers.
The ability to visualize and manipulate single DNA molecules can provide unique and valuable insights. Doyle's lab directly observes single DNA molecules using fluorescence microscopy and manipulates them in custom built microdevices. DNA experiments focus on designing new separation techniques for lab-on-chip devices, understanding polymer dynamics in complex flows and confined geometries, and studying single molecule biophysics. To complement and often guide these experimental studies, large-scale Brownian dynamics simulations are performed. The Lab is currently exploring rational design strategies to optimize DNA sequencing techniques and separations in microlithography arrays.
In microparticle work, the Lab has developed a number of new flow-based synthesis techniques which combine microfluidics with lithography. These synthesis techniques allow for the production of complex microparticles. Enabled by these technologies, encoded particles are developed for the multiplexed detection of proteins and nucleic acids. Other applications include drug delivery and pharmaceutical processing. Additionally, these systems are used to design custom mechanically soft or magnetic particles and study their response in fields or flows.
(summary updated 9/2010)
Recent Work
Projects
March 14, 2024
Department of Chemical Engineering
Functional Hydrogel Microparticles for Sustainable Water Treatment
Principal Investigator
Patrick Doyle
July 1, 2019
Deshpande Center for Technological Innovation
Multiplexed Measurement of miRNA in Tissue Sections
Principal Investigator
Patrick Doyle
June 5, 2019
Department of Chemical Engineering
Microparticle Systems for the Removal of Organic Micropollutants
Principal Investigators
Patrick Doyle
,
Rafael Gomez-Bombarelli
May 1, 2017
Department of Chemical Engineering
Microfluidic Modules for Point-of-Care Testing
Principal Investigator
Patrick Doyle
January 25, 2017
Department of Chemical Engineering
Polymer Dynamics of Knotted DNA
Principal Investigator
Patrick Doyle
October 21, 2013
Department of Chemical Engineering
Dynamics of Self-Entangled DNA Molecules
Principal Investigator
Patrick Doyle
March 16, 2009
Department of Chemical Engineering
DNA Electrophoresis in Microfluidic Devices
Principal Investigator
Patrick Doyle
March 16, 2009
Department of Chemical Engineering
Microparticle Synthesis Using Microfluidics
Principal Investigator
Patrick Doyle
March 16, 2009
Department of Chemical Engineering
Multiplexed Biomolecule Detection Using Barcoded Particles
Principal Investigator
Patrick Doyle
October 1, 2007
Department of Chemical Engineering
DNA Dynamics in Nanofluidic Devices
Principal Investigator
Patrick Doyle
September 27, 2007
Department of Chemical Engineering
Single-Molecule DNA Mapping in a Fluidic Device
Principal Investigator
Patrick Doyle
September 27, 2007
Department of Chemical Engineering
Barcoded Microparticles for Multiplexed Detection
Principal Investigator
Patrick Doyle
July 25, 2005
Department of Chemical Engineering
Dynamics of Biopolymers and Complex Fluids\n
Principal Investigator
Patrick Doyle
July 25, 2005
Department of Chemical Engineering
Microrheology of Extracellular Matrices and Biopolymers
Principal Investigator
Patrick Doyle
July 25, 2005
Department of Chemical Engineering
Brownian Dynamics Simulations of Complex Molecules
Principal Investigator
Patrick Doyle
July 25, 2005
Department of Chemical Engineering
Superparamagnetic Colloids in Microfluidic Devices\n
Principal Investigator
Patrick Doyle
Related Faculty
Prof. Jefferson W Tester
Professor of Chemical Engineering, Emeritus
Prof. Clark K Colton
Professor of Chemical Engineering
James R Hardsog
Systems Administrator