Multiplexed Measurement of miRNA in Tissue Sections

Spatially resolved gene expression patterns are emerging as a key component of medical studies, including companion diagnostics, yet technologies for quantification and multiplexing are limited. This project is developing a method to perform spatially-resolved and multiplex microRNA measurements directly from formalin-fixed, paraffin-embedded tissue. This technology could be used to quantify the heterogeneities in tissue samples and lead to informed biomarker-based diagnostics.