Prof. Bryan Bryson

Associate Professor of Biological Engineering

Primary DLC

Department of Biological Engineering

MIT Room: NE46-958

Areas of Interest and Expertise

Computational Modeling
Infectious Disease
Microbial Pathogenesis
Microbial Systems
Systems Biology

Research Summary

Mycobacterium tuberculosis remains one of the world’s most deadly bacteria resulting in infection in nearly a third of the global population and millions of deaths per year. Recent advances in our understanding of tuberculosis infection demonstrate that infection within a given individual is highly heterogeneous; however, the determinants that drive lesions towards complete bacterial sterilization remain poorly understood. We are interested in developing new tools to dissect the complex dynamics of bacterial infection at a variety of scales ranging from single cells to infected animals sitting in both “reference frames” by taking both an immunologist’s and a microbiologist's perspective. Combining new technologies with classical approaches, we are focused on answering a critical question: “how can we manipulate the immune system to improve bacterial control?”

Understanding and Predicting the Host and Bacterial Determinants of Bacterial Fate
Developing Novel Tools to Interrogate Bacterium: Host Interactions with Single Cell Resolution
Reprogramming the Innate Immune System to Improve Bacterial Control Through Systematic Dissection of Innate Response Pathways

Recent Work