4.4.23-Health-Roche

Conference Video|Duration: 28:44
April 4, 2023
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    Cyclical dynamic expansion and contraction are essential to the life-sustaining function of organs, exemplified by the heart and lungs. These continuous movements coupled with complex tissue architecture and composite mechanical properties pose considerable challenges to augmenting impaired organ function. My research is providing paradigm-shifting approaches to overcome those challenges, by blending principles of pathophysiology, biomechanics and mechanical engineering with state-of-the-art materials and robotics. In this talk I will speak about three interrelated research streams (i) augmenting the remaining native function in failing organs and biological systems to restore functionality, (ii) introducing technologies to replace or repair focal deficits in tissues and deliver therapy and (iii) developing physiologically realistic in vitro, in vivo, ex vivo and in silico  approaches suitable for testing cardiac or pulmonary technologies. I will review my group’s overarching approach to designing these technologies, and how these endeavors have opened up possibilities for further understanding of the biomechanics associated with their targeted organ systems. I will illustrate exemplary work from each research strand with specific vignettes. Finally, I will discuss the potential impact of our work, and how co-designing multimodal simulation models with clinical and industrial partners can not only lead to enhanced implantable device design and testing, but also to further understanding of the fundamental mechanical influencers of pathophysiology and intervention strategies.
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  • Video details
    Cyclical dynamic expansion and contraction are essential to the life-sustaining function of organs, exemplified by the heart and lungs. These continuous movements coupled with complex tissue architecture and composite mechanical properties pose considerable challenges to augmenting impaired organ function. My research is providing paradigm-shifting approaches to overcome those challenges, by blending principles of pathophysiology, biomechanics and mechanical engineering with state-of-the-art materials and robotics. In this talk I will speak about three interrelated research streams (i) augmenting the remaining native function in failing organs and biological systems to restore functionality, (ii) introducing technologies to replace or repair focal deficits in tissues and deliver therapy and (iii) developing physiologically realistic in vitro, in vivo, ex vivo and in silico  approaches suitable for testing cardiac or pulmonary technologies. I will review my group’s overarching approach to designing these technologies, and how these endeavors have opened up possibilities for further understanding of the biomechanics associated with their targeted organ systems. I will illustrate exemplary work from each research strand with specific vignettes. Finally, I will discuss the potential impact of our work, and how co-designing multimodal simulation models with clinical and industrial partners can not only lead to enhanced implantable device design and testing, but also to further understanding of the fundamental mechanical influencers of pathophysiology and intervention strategies.
Locked Interactive transcript

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