4.4.23-Health-Lieberman

Conference Video|Duration: 26:27
April 4, 2023
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    A new generation of rationally designed, durably colonizing, microbial therapeutics has yet untapped potential to sustainably treat disease and promote wellness. Fecal transplants are famously effective in treating people with recurrent Clostridium dificile infections. Recurrent urinary tract infections have been treated with asymptomatic bacteria that outcompete pathogens. Even for diseases that are not caused by bacteria, microbiome-based therapies may one day improve drug metabolism, supply vital nutrients, and modulate the immune system (including for cancer therapy). Probiotics for the skin may one day improve wound healing, protect skin from UV damage, or outcompete Staphylococcus aureus to manage atopic dermatitis. I will share a few stories from the lab that demonstrate the potential of the microbiome to treat disease and improve wellness, and the particular value in tracking the microbiome at the level of individual bacteria mutations for understanding in vivo mechanism.
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  • Video details
    A new generation of rationally designed, durably colonizing, microbial therapeutics has yet untapped potential to sustainably treat disease and promote wellness. Fecal transplants are famously effective in treating people with recurrent Clostridium dificile infections. Recurrent urinary tract infections have been treated with asymptomatic bacteria that outcompete pathogens. Even for diseases that are not caused by bacteria, microbiome-based therapies may one day improve drug metabolism, supply vital nutrients, and modulate the immune system (including for cancer therapy). Probiotics for the skin may one day improve wound healing, protect skin from UV damage, or outcompete Staphylococcus aureus to manage atopic dermatitis. I will share a few stories from the lab that demonstrate the potential of the microbiome to treat disease and improve wellness, and the particular value in tracking the microbiome at the level of individual bacteria mutations for understanding in vivo mechanism.
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