11.2.20-Laufffenburger

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  A vital challenge that the vast majority of biological research must address is how to translate observations from one physiological context to another—most commonly from experimental animals (e.g., rodents, primates) or technological constructs (e.g., organ-on-chip platforms) to human subjects.  This is typically required for understanding human biology because of the strong constraints on measurements and perturbations in human in vivo contexts.  Direct translation of observations from experimental animals to human subjects is generally unsatisfactory because of significant differences among organisms at all levels of molecular properties from genome to transcriptome to proteome and so forth.  Accordingly, addressing inter-species translation requires an integrated experimental/computational approach for mapping comparable but not identical molecule-to-phenotype relationships.  This presentation will describe methods we have developed for a variety of cross-species translation examples, demonstrated on applications in inflammatory pathologies and cancer

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