11.2.20-Kamm

• Video details

  One of the major applications of living machines today is in the development of microfluidic platforms within which matrix and cells can be seeded in order to create a model of organ or tissue function, either in health or disease.  These are often referred to as microphysiological systems (MPS), and are increasingly used by the research community to study disease processes and identify new therapies.  They are also being adopted by the pharma and biotech industries for drug development and screening.  This presentation will focus on two approaches to engineer MPS, either by a traditional top-down engineering approach or by drawing upon the emergent properties of cell populations to self-assemble into organ-like systems with the desired form and function.  Several examples from our current research will be presented ranging from models of metastatic cancer to Alzheimer’s disease.

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