A shift to a more decentralized, blockchain-based internet will have important implications for the enterprise. The next phase of the internet, often referred to as Web3, will require adapting to a shifting external environment. Changes to customer identity and data sovereignty will have important implicants for marketing, product design and data analytics. Web3 will also require internal adjustments. These changes include developing new business processes that are more on-chain and involve new technologies like NFTs, the Metavserse, and tokenized digital twins. A shift from static to dynamic certificates will change internal training and development in ways that will incentives and reward continuous learning. In short, web3 will create a new enterprise frontier, requiring a new wave of innovation and investment to keep pace.