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Over the past decade, research on the development of multi-cellular engineered living systems has produced technologies and capabilities that are now positioned to facilitate a fundamental understanding of disease processes and can help to identify innovative therapeutic strategies. Globally, while many labs are engaged in the development of new and more sophisticated organ models for drug discovery and screening, there is an urgent need to disrupt the way drugs are currently developed. Our vision is to humanize drug development based on a new approach that integrates microphysiological system models of disease and enhanced model control/interrogation, with modern systems biology and systems immunology. This is the focus of Living Machines, one of five threads in the New Engineering Education Transformation (NEET) program to reimagine engineering education at MIT in which sophomores, juniors and seniors, under the guidance of faculty mentors and instructors, learn, discover, build and engineer living systems for broad applications in biotechnology and medical devices. This webinar will share the perspectives of 3 MIT faculty, their research capabilities and interests in which NEET students can participate, and that of several NEET students and what they can or hope to achieve.