The Infinite Loop: ML for Discovery, Delivery, and Rapid Manufacturing of Potential Medicines Bradley L. Pentelute Professor, MIT Department of Chemistry
The thousands of inputs a single neuronal cell receives can interact in complex ways that depend on their spatial arrangement and on the biophysical properties of their respective dendrites. For example, operations such as coincidence detection, pattern recognition, input comparison, and simple logical functions can be carried out locally within and across individual branches of a dendritic tree. In this talk, we will present the hypothesis that the brain leverages these fundamental integrative operations within dendrites to increase the processing power and efficiency of neural computation. We will focus on sensory processing and spatial navigation, with the goal of understanding the mechanistic basis of these brain functions.
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Formate Economy and AI-Assisted Catalyst Search Ju Li Battelle Energy Alliance Professor, MIT Department of Nuclear Science & Engineering Professor, MIT Department of Materials Science and Engineering
Carbon efficiency is one of the most pressing problems of carbon dioxide electroreduction today. While there have been studies on anion exchange membrane electrolyzers with carbon dioxide (gas) and bipolar membrane electrolyzers with bicarbonate (aqueous) feedstocks, both suffer from low carbon efficiency. In anion exchange membrane electrolyzers, this is due to carbonate anion crossover, whereas in bipolar membrane electrolyzers, the exsolution of carbon dioxide (gas) from the bicarbonate solution is the culprit. Here, we first elucidate the root cause of the low carbon efficiency of liquid bicarbonate electrolyzers with thermodynamic calculations and then achieve carbon-efficient carbon dioxide electro- reduction by adopting a near-neutral-pH cation exchange membrane, a glass fiber intermediate layer, and carbon dioxide (gas) partial pressure management. We convert highly concentrated bicarbonate solution to solid formate fuel with a yield (carbon efficiency) of greater than 96%. A device test is demonstrated at 100 mA cmÀ2 with a full-cell voltage of 3.1 V for over 200 h. ["A carbon-efficient bicarbonate electrolyzer," Cell Reports Physical Science 4 (2023) 101662]
Guoping Feng
We are in the process of transitioning to a new economy where highly complex, custom products are manufactured on demand by automated manufacturing systems. For example, 3D printers are revolutionizing production of metal parts in aerospace, automotive, and medical industries. Manufacturing electronics on flexible substrates opens the door to a whole new range of products for consumer electronics and medical diagnostics. In this talk, I will show that computation is an integral component of modern design and manufacturing. I will demonstrate how computational tools allow creating digital materials with precisely controlled physical properties and how these digital materials are used to automatically synthesize product designs with desired specifications. I will also show how computational tools enable real-time, closed-feedback loop in additive manufacturing systems to improve their reliability and to fabricate complex products with integrated electronics.
Physical neural networks made of analog resistive switching processors are promising platforms for analog computing and for emulating biological synapses. State-of-the-art resistive switches rely on either conductive filament formation or phase change. These processes suffer from poor reproducibility or high energy consumption, respectively. Our work, on one hand, focuses on understanding and controlling the variability of the conductive filament formation in insulating oxide materials. On the other hand, we are innovating alternative synapse designs that rely on a deterministic charge-controlled mechanism, modulated electrochemically in a solid state, and that consists of shuffling the smallest cation, the proton. As typical throughout our research, here, too, we combine experimental synthesis, fabrication, and characterization with first principles-based computational modeling to gain a deep understanding and control of these promising devices.