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19282 search results found
  • J. Christopher Love - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 31:36

    Fast and Modular Manufacturing Systems for Biopharmaceuticals and Vaccines

    Recombinant biopharmaceuticals and vaccines represent a significant class of therapeutics and preventions. While the industry has established efficient platformed processes for the production of monoclonal antibodies at multi-ton scales, the improved precision of therapeutic indications and expanding molecular designs (such as bispecific antibodies, nanobodies, and others) add new challenges for the timely and cost-effective production of emerging therapeutic concepts. This talk will present an integrated approach to biomanufacturing that combines automated end-to-end production and purification along with a fast and engineering-friendly alternative host to enable a flexible platform for next-generation manufacturing. Examples in both biopharmaceuticals and vaccines will be presented.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Andrew W. Lo - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 31:58

    Estimating and Predicting Clinical Trial Success Rates: A Data Science Approach

    All investors require some understanding of the potential risk and reward of a given venture before they’re willing to invest, and the less they know about it, the less capital will be available. This is especially true with biomedical assets in which the risks and rewards are equally outsized and hard to evaluate. Therefore, a prerequisite for addressing the so-called “Valley of Death” in early-stage biomedical R&D funding is better risk analytics. In this talk, Prof. Lo will describe his latest research on estimating historical probabilities of success for clinical trials and then applying machine-learning techniques to predict future success rates across a variety of drug/indication pairs. With more accurate assessments of these success probabilities, capital can be deployed more efficiently and at lower cost, thereby bringing greater amounts of capital into the biopharma industry at a time when capital is needed most.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Klavs Jensen - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 29:28

    Machine Learning and Process Intensification in Pharmaceutical Development and Continuous Manufacturing

    Machine learning of chemical information is applied to computer aided chemical synthesis - the planning of reaction paths to a given molecular target from purchasable starting materials. The use of robotics with expert user input enable execution of identified reaction paths in an automated modular continuous flow platform. Advances in automated screening and optimization of chemical reactions accelerate translation of laboratory discoveries to manufacturing. Finally, process intensification is illustrated with on-demand synthesis pharmaceuticals in plug-and-play, manually reconfigurable, refrigerator-sized manufacturing platforms.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Eli Paster - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 17:11

    PolyJoule: Stationary Energy Storage: The Epicenter of Renewable Adaptation and the 21st Century Grid

    Stationary energy storage seeks to disrupt the electricity markets on a global scale. Safe, inexpensive energy storage, the missing link in the electricity grid’s 140-year history, will: (1) supplement large capital infrastructure upgrades with low-cost storage; (2) pair with renewables to realize cost effective alternatives to fossil fuel generation; (3) upturn legislative and regulatory restrictions, ushering in digital and energy-sharing economic and societal opportunities.

    PolyJoule has developed a non-lithium form of energy storage that is built purposely for the electricity grid. Safety is molecularly designed into our battery chemistry, streamlining permitting and usability. PolyJoule batteries can respond to both base loads and peak loads in microseconds, allowing the same energy storage system to participate in multiple power markets and deployment use cases. Upfront asset costs are low. Lifetime battery reliability is high. This lecture will introduce PolyJoule, our proprietary energy storage chemistry, its performance profile, and how congested electricity grids, renewable adaptation, and environmental tidal waves all benefit from low-cost, high-power energy storage assets.

    2019 MIT Madrid Symposium
  • Marshall Chapin - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 30:19

    Indigo Technologies: In-wheel motors - the key to unlocking tomorrow's mobility

    Technology is changing the world at a blistering pace, and established industries are being rapidly displaced, often in a matter of years. Airbnb, Uber, Netflix, Spotify - all multi-billion dollar businesses which unseated highly entrenched incumbents. Nowhere is this more evident than the transportation sector, and the highly integrated and coordinated automotive industry.

    The automotive industry is telling the world that it's reinventing itself too, but the supposedly groundbreaking new vehicles they offer are largely built on the same century-old vehicle designs. Global need for immediate order-of-magnitude improvements in vehicle efficiency combined with a rise in mobility-as-a-service preferences and autonomous systems mean the traditional incremental change in vehicle design will not be sufficient for auto makers to remain competitive.

    Indigo Technologies is working to break this vehicle design paradigm. The vehicles of tomorrow need to be highly efficient, lightweight, modular, and flexible, using advanced manufacturing techniques and materials. Indigo unlocks this future with its core technology, an innovative in-wheel motor with integrated active suspension, which frees vehicle designers from the constraints of encapsulating a traditional powertrain and allows for efficient design. Marshall will explain how this technology, as well as Indigo's wireless power transfer system, is helping forward-thinking OEMs design and build the future of mobility.

    2019 MIT Madrid Symposium
  • Round Table - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 47:0

    Roundtable Discussion

    2019 MIT Madrid Symposium
  • Patrick Anquetil - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 32:8

    Portal Instruments: Medical Injections Transformed with Connected Needle-free Technology

    The adherence to treatment in injectable therapies for chronic diseases (e.g. rheumatoid arthritis, multiple sclerosis, psoriasis, Crohn’s disease, etc.) is extremely low (45% - 60%) and in part due to the inconvenience and anxiety associated with using needles and syringes. Biological medicines treating those conditions cannot be formulated as pills and as such there is a huge opportunity for new technologies replacing needles and syringes to transform the perception, approachability and market penetration of such therapies. Portal has developed a next-generation needle-free drug delivery platform that is computer-controlled, easy to use and patient preferred. Real time injection tracking via cloud-based connectivity enables patients and their care teams to manage their condition better and take charge of their wellbeing. Issued from Professor Ian Hunter’s research at the MIT BioInstrumentation Lab, this technology leverages advances in multiple disciplines such as high-power density electromagnetic actuators, ARM-based micro-electronics and embedded software, and energy storage. The company is at the commercial stage, preparing to launch a drug/device combination product with Takeda Pharmaceuticals in the field of Inflammatory Bowel Diseases. A live demonstration of the Portal Device will be presented at the Symposium.

    2019 MIT Madrid Symposium
  • Lynette Jones - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 19:31

    MICA: Revolutionizing STEM Education

    The traditional lecture and laboratory approach used in teaching science and engineering has dominated education at high schools and universities for centuries. Although classroom demonstrations are sometimes used to provide instructive and motivating examples of taught concepts, in large classes they are difficult to see and without direct “hands on” involvement of the students have limited effect. Our initiative to address this shortcoming is MICA (Measurement, Instrumentation, Control and Analysis) an educational approach designed for subjects in Science, Technology, Engineering and Mathematics (STEM). Students interact with an experimental workstation (MICA workstation) to conduct experiments, analyze data, undertake parameter estimation, and fit mathematical models, while learning the theory and relevant subject history under the guidance of a virtual tutor (MICA avatar). As students interact with the MICA workstations their skill level, rate of learning and progress is quantified. Based on these data, deep learning techniques and mathematical modelling are then used to generate an individualized model of a student’s state of knowledge which is augmented every time the student interacts with a MICA workstation. This ‘state of knowledge’ model is then used by the MICA tutor to personalize (and eventually optimize) the teaching pace as well as the way in which subject material is delivered.

    2019 MIT Madrid Symposium
  • Olivier de Weck - 2019 RD Conference

    November 20, 2019Conference Video Duration: 41:11

    Staircase to Utopia: Advances in Technology Roadmapping

    This presentation will present a new state of the art framework for technology roadmapping based on a similar approach implemented at Airbus from 2016-2018 and demonstrated using the example of stratospheric solar-powered electric aircraft. The framework includes four steps beginning with a quantitative assessment of the current state of technology and competitive analysis and concludes with a risk-optimized R&D portfolio with specific Figure-of-Merit (FOM) based targets. The presentation will summarize the 17 technologies for which roadmaps are being developed in Fall 2019 as part of MIT’s new graduate class 16.887/EM.427 on Technology Roadmapping and Development.
     
    2019 MIT Research and Development Conference
  • Martin Culpepper - 2019 RD Conference

    November 20, 2019Conference Video Duration: 41:52

    The Latest Academic Arms Race - Making + Entrepreneurship - Is Going to Matter To You

    Several decades back, the hands-on capstone course was a step change for technology education. It started at schools like MIT and spread worldwide. We now expect students have some experience in "thinking + doing," in fact, it is often necessary for university accreditation.

    We are in the midst of an impending step change, and again, schools like MIT are in competition to lead this change. It has led to an "arms race" in higher education that will shape the future people that work with/for you. Hundreds of millions of dollars are being spent by universities in a competition to create innovation ecosystems that produce technology innovators that have making + innovation skill sets.

    You're going to want to know about these people, who is best at educating/creating them, and how to gain a competitive advantage in hiring them. In this talk, I'm going to help you figure that out.

     
    2019 MIT Research and Development Conference

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