Recent innovations in semiconductor technology and biochemistry have brought about opportunities for realizing the long sought-after dream of personalized care. Periodic clinical-quality readings of biomarkers and vital signs provide the data needed to build a digital twin of one’s biological profile based on an AI-generated model. The digital twin will be a powerful tool for prevention, diagnosis, prognosis as well as therapeutic plans. The “Waves, Bits, and Molecules”” lab at MIT envisions transformational improvements in healthcare and life quality through innovations in advanced technologies at the intersection of semiconductor technology, biochemistry, and machine learning. In this talk, we review innovative semiconductor technologies such as electrochemical, Ultrasonic, photoacoustic, RF, and magnetic sensors and nanoactuators, which can transform the future of personalized diagnostics and treatments.