Humanizing Drug Development: Neurovascular Models of Neurological Diseases
Francesca Michela Pramotton Postdoctoral Research Fellow, MIT Department of Biological Engineering The Humanizing Drug Development (HDD) consortium focuses on developing an iPSC-derived neurovascular model of neurological diseases to investigate different transporter routes for drug delivery into the brain and for drug screening. Isogenic, self-assembled vascular networks of the blood-brain barrier are interfaced to midbrain organoids carrying familial Parkinson’s or Alzheimer’s disease mutations. These microphysiological systems are key to studying disease development and researching therapeutic possibilities.