3D Microphysiological Skin Models for Subcutaneous Delivery of Therapeutics Maria Proestaki Postdoctoral Associate, MIT Department of Biological Engineering The Humanizing Drug Development (HDD) Skin consortium focuses on developing a 3D microphysiological skin model for subcutaneous delivery of monoclonal antibodies or other therapeutics. The model consists of a self-assembled and perfusable blood vasculature while a lymphatic vasculature is also included in one integrated microfluidic device. This human skin microvascular model can be used for ADME or immune response studies and it can serve as a tool for predicting drug bioavailability.