Rugged, High Sensitivity, Integrated, Photonic Chemical Sensing

Thie project seeks to endow surfaces with the ability to inactivate human viruses, in particular pathogenic strains of influenza virus. The proposed work builds on the previous 4 years of ISN research (ISN-1 Project 3.1) focused on creating novel, non-leaching, nano-inspired, bactericidal and also fungicidal surfaces. Recently, in ISN-sponsored studies, Klibanov discovered the efficacy of N-dodecyl,N-methyl-polyethylenimine coatings for reducing the viral titer of the H1N1 (WSN/33) strain of influenza. Project 4.1.3 proposes to expand, investigate, rationalize, exploit, and thoroughly explore these initial findings. Hammond will derivatize hyperbranched polyelectrolytes tailor-made for virucidal applications and investigate their incorporation onto surfaces using layer-by-layer techniques. Chen (new ISN PI) will supervise all virucidal and toxicity testing and provide a mechanistic examination of virucidal action. The nano-inspired hydrophobic virucidal polymers dissolved in organic solvents would be “painted” (e.g., sprayed or brushed) onto a variety of objects and surfaces of military relevance, including weapons, uniforms, interior walls, barrack furniture and fixtures, and air ducts and filters. These coatings should drastically reduce the spread of influenza (and possibly other viral) infections. Note that even mild flu adversely affects the battle readiness and performance of the Soldier and other military, security, and support personnel.