Principal Investigator Leonard Guarente
Co-investigator H Horvitz
Sirtuins have been implicated in nutrition-related longevity through a variety of mechanisms. It was recently demonstrated that SIRT1 expression is altered in progeny in response to maternal high-fat diets in non-human primates. Because of the ability of SIRT1 to epigenetically alter gene expression in response to one’s nutritional state, we are interested in exploring whether embryonic SIRT1 mediates health and longevity in mammalian offspring exposed to different prenatal nutritional regimens.