Principal Investigator Elizabeth Nolan
Project Start Date May 2011
The goal of this project is to identify genes that are required to stabilize DNA replication under hyperreplicative conditions as we expect mutations in the human homologues of these genes to be predisposed to environmental - and/or oncogenes induced carcinogenesis as well as potentially good chemotherapy targets. Cancer cells grow under hyper-proliferative conditions and may exhibit a greater dependency on these genes than slower growing primary tissue. We therefore hope to build a new connection between the replication stress response and metabolism. Finally, the vector system and the flow unit we will build to perform these arrays will be of use to the community and can be applied to many other studies.