Principal Investigator Jacqueline Lees
Co-investigators Frank Gertler , Richard Hynes , Phillip Sharp , Forest White
Project Website http://ki.mit.edu/research/metastasis
Primary tumors are seldom lethal -- most cancer deaths are caused by metastasis. Cancer cells mutate and spread to far-flung regions of the body, where they are difficult to investigate and eradicate. Too little is known about the molecular and cellular changes that drive metastasis. Under the aegis of the Ludwig Center for Molecular Oncology, we are identifying the genes that encourage metastastic spread and allow cancer cells to survive and thrive in disparate locations. We are also devising methods to identify and visualize sites of metastasis earlier in the disease. Armed with this knowledge, we aim to combat metastasis before it begins and destroy cancer cells wherever they may hide.