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Prof. Richard O Hynes

Virginia and Daniel K Ludwig Professor for Cancer Research
Howard Hughes Medical Institute (HHMI) Investigator
Senior Associate Member, Broad Institute

Primary DLC

Department of Biology

MIT Room: 76-361
(617) 253-6422

Areas of Interest and Expertise

Cell Biology
Cancer Biology
Molecular and Cell Biological Analyses of Cellular Proteins, Especially Fibronectins and Integrin Adhesion Receptors
Analysis of the Structure of and Interactions Between Molecules of the Cytoskeleton, Cell Surface and Extracellular Matrix
Cell Migration and Adhesion During Embryogenesis, Inflammation Hemostasis, Thrombosis, and Malignant Transformation
Alterations in Oncogenic Transformation and Roles in Cell Form and Behavior During Development and Pathogenesis
Molecular Medicine and Human Disease
Biological Oceanography
Developmental Biology: Role of Cell Adhesion in Mammalian Development
Stem Cells

Research Summary

The Hynes lab is interested in understanding the molecular basis of cell adhesion and its involvement in cell behavior including contributions to various human diseases, especially cancer progression, including invasion, metastasis and angiogenesis. Around 5-10% of the genes in a mammalian genome are involved in cell adhesion. The lab uses genetically engineered mice and cells derived from them, combined with molecular and cell biological methods, to investigate the roles of adhesion molecules in both normal physiology and in mouse models of human diseases.

Recent Work

Related Faculty

Dr. Tomas Pluskal

Postdoctoral Associate

Eugene Lee

Visiting Scientist

Dr. Jens K Plassmeier

Research Affiliate