Principal Investigator Paul Barton
Several CSBi laboratories are using the ABACUSS software platform, which we developed to aid in modeling and simulating complex processes. ABACUSS provides a high-level environment with a graphical interface that lets users formulate, debug and numerically solve large-scale dynamic models of the kinetics of biochemical networks. ABACUSS currently supports the simulation, sensitivity analysis and parameter estimation of large-scale discrete/continuous models based on differential-algebraic equations. Currently, we are incorporating into ABACUSS new algorithms that we developed for mixed-integer and dynamic optimization.