Skip to main content
MIT Corporate Relations
MIT Corporate Relations
Search
×
Read
Watch
Attend
About
Connect
MIT Startup Exchange
Search
Sign-In
Register
Search
×
MIT ILP Home
Read
Faculty Features
Research
News
Watch
Attend
Conferences
Webinars
Learning Opportunities
About
Membership
Staff
For Faculty
Connect
Faculty/Researchers
Program Directors
MIT Startup Exchange
User Menu and Search
Search
Sign-In
Register
MIT ILP Home
Toggle menu
Search
Sign-in
Register
Read
Faculty Features
Research
News
Watch
Attend
Conferences
Webinars
Learning Opportunities
About
Membership
Staff
For Faculty
Connect
Faculty/Researchers
Program Directors
MIT Startup Exchange
Back to Faculty/Researchers
Prof. Matthew D Shoulders
Class of 1942 Professor of Chemistry
Margaret MacVicar Faculty Fellow
Primary DLC
Department of Chemistry
MIT Room:
16-573A
(617) 452-3525
mshoulde@mit.edu
https://chemistry.mit.edu/profile/matthew-d-shoulders/
Assistant
Betty Lou McClanahan
(617) 253-0630
blm@mit.edu
Areas of Interest and Expertise
Understand Protein Folding Behavior, Mechanisms
Development of Small Molecule Tools and Drugs
Related Diseases Including Cancer and Arthritis
Research Summary
The Shoulders Laboratory (1) studies how cells fold proteins and (2) develops and applies next-generation protein engineering and directed evolution techniques to address biotechnology challenges.
The Shoulders Group is interested in (1) understanding how cells fold proteins and (2) using the tools of evolution to understand proteostasis and develop next-generation biomolecules. In the area of cellular protein folding, they study how protein misfolding and aggregation leads to diseases of the extracellular matrix (especially collagenopathies), and seek new treatments for these disorders. They also study how chaperones and quality control mechanisms impact the mutational space accessible to client proteins, particularly oncogenes and rapidly evolving RNA viruses — beyond fundamental interest, this research could lead to new types of treatments for cancer and viral infections. In biotechnology-oriented work, they invent new and efficient in vivo directed evolution strategies that they use to create valuable biotechnologies. Applications in this area range from new types of genome targeting agents to improving enzymes involved in biological carbon capture that can help to address climate change and support resilient agriculture.
Recent Work
Projects
September 1, 2021
Deshpande Center for Technological Innovation
Continuous Directed Evolution in Mammalian Cells
Principal Investigator
Matthew Shoulders
October 25, 2018
Department of Chemistry
Chemical Biology Method Development to Enable the Study of Metazoan Proteostasis
Principal Investigator
Matthew Shoulders
October 25, 2018
Department of Chemistry
Collagen Folding, Misfolding and Quality Control
Principal Investigator
Matthew Shoulders
October 25, 2018
Department of Chemistry
Metazoan Glycobiology and New Proteostasis Network Functions
Principal Investigator
Matthew Shoulders
October 25, 2018
Department of Chemistry
Protein Evolution, RNA Viruses and Chaperones
Principal Investigator
Matthew Shoulders
October 20, 2015
Department of Chemistry
Continuous Directed Evolution of Biomolecules in Human Cells for Medical Research
Principal Investigator
Matthew Shoulders
September 17, 2013
Department of Chemistry
Shoulders Laboratory
Principal Investigator
Matthew Shoulders
Related Faculty
Prof. Bin Zhang
Associate Professor of Chemistry
Prof. Mei Hong
Leighty Professor of Chemistry
Dr. Ajay Kumar Pande
Research Affiliate