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Prof. Darrell J Irvine
Professor of Materials Science and Engineering
Professor of Biological Engineering
Howard Hughes Medical Institute Investigator (HHMI)
Primary DLC
Department of Materials Science and Engineering
MIT Room:
76-261C
(617) 452-4174
djirvine@mit.edu
https://dmse.mit.edu/faculty/darrell-j-irvine/
Assistant
Val Corapi
(617) 253-5819
vcorapi@mit.edu
Areas of Interest and Expertise
Health and Medicine
Soft Matter
Characterization
Synthesis and Processing
Research Summary
Engineering approaches grounded in immunology hold the key to the discovery and development of novel treatments for cancer, infectious disease, and autoimmunity. To this end, the overarching goal of the Irvine laboratory is to engineer immunity through a fusion of immunology with biotechnology and materials chemistry, employing a materials science-centric approach to create new therapies based on the controlled modulation of the immune system. Our work toward this goal divides into three complimentary themes, all focused on adapting engineering principles to enhance the ability of the immune system to prevent and treat human disease:
(1) Smart materials and nanotechnology for enhanced vaccines against infectious disease and cancer. We develop synthetic materials as adjuvants and delivery systems that shape the immune response elicited by vaccination, and study the underlying biological mechanisms governing this response.
(2) Nanomaterials-enabled immunotherapy. Here we are exploring strategies to promote, amplify, and maintain anti-tumor immune responses by controlling where and when cells of the immune system receive stimulatory cues, and seeking to overcome the immunosuppressive milieu developed in solid tumors.
(3) New tools for manipulating and monitoring the immune system. We develop biomaterials-based approaches to monitor and manipulate immune cells, to increase our fundamental understanding of the immune system and invent new methods for monitoring immunity in humans.
Recent Work
Projects
November 3, 2016
Department of Materials Science and Engineering
Lymph Node-Targeted Molecular Vaccines
Principal Investigator
Darrell Irvine
November 3, 2016
Department of Materials Science and Engineering
T-Cell-Mediated Targeting of Therapeutics to HIV Reservoirs
Principal Investigator
Darrell Irvine
May 4, 2015
Department of Materials Science and Engineering
Nanomaterials-Enabled Immunotherapy
Principal Investigator
Darrell Irvine
May 4, 2015
Department of Materials Science and Engineering
New Tools to Interrogate the Immune System
Principal Investigator
Darrell Irvine
May 4, 2015
Department of Materials Science and Engineering
Vaccine Design Using Smart Materials and Nanotechnology
Principal Investigator
Darrell Irvine
April 18, 2014
Department of Materials Science and Engineering
Nanotechnology for Stimulating, Sampling, and Monitoring Immunity
Principal Investigator
Darrell Irvine
April 18, 2014
Department of Materials Science and Engineering
Complementary Wound-Healing Strategies Enabled by Synthetic Biology and Nanotechnology
Principal Investigator
Darrell Irvine
February 25, 2013
Department of Materials Science and Engineering
Targeting Immunosuppression Blockade to T Cells for Cancer Immunotherapy
Principal Investigator
Darrell Irvine
March 7, 2008
Department of Materials Science and Engineering
Cancer Immunology: Engineering the Immune System to Fight Cancer
Principal Investigator
Darrell Irvine
October 24, 2007
Department of Materials Science and Engineering
The Irvine Lab
Principal Investigator
Darrell Irvine
January 11, 1998
Department of Materials Science and Engineering
Program in Polymers and Soft Matter (PPSM)
Principal Investigator
Darrell Irvine
Related Faculty
Rachel Chava Kurchin
Graduate Student
Dr. Jonathan Sander
Postdoctoral Fellow
Prof. Caroline A Ross
Ford Foundation Professor of Engineering