Prof. Domitilla Del Vecchio

Professor Del Vecchio's group focuses on model-based analysis, design, and control of biomolecular networks in living cells. The objective is to make the engineering of synthetic genetic circuits in living organisms more robust to context, modular, and hence more scalable. One of the target applications is the design of synthetic genetic circuits that control cell fate to produce patient-specific somatic cells for regenerative medicine. The approach is grounded on rigorous mathematical analysis of physics-based models of biological network dynamics, on control-theoretic tools for design, and on theory-educated experiments in living cells, from bacterial to mammalian.