Prof. Elazer R Edelman

Director, Institute for Medical Engineering and Science (IMES)
Edward J Poitras Professor in Medical Engineering and Science
Professor of Medicine, Harvard Medical School (HMS)
Senior Attending Physician, Brigham and Women’s Hospital (BWH)

Primary DLC

Institute for Medical Engineering and Science

MIT Room: E25-438

Areas of Interest and Expertise

Cardiovascular Repair
Tissue Engineering
Drug Delivery and Growth Factors
Biomaterials
Cell Biology
Atherosclerosis
Image Analysis
Cardiovascular Growth Control
Physiology
Cell and Molecular Biology
Drug Delivery
Transport
Center for Innovative Minimally Invasive Therapy (CIMIT)
Atherogenesis
Therapeutic Technologies
Future of Healthcare

Research Summary

Dr. Edelman’s research melds his clinical and medical training and interests, focusing on understanding how tissue architecture and biochemical regulation contribute to local growth control. Edelman and his students were among the first to validate the hypothesis that proliferative vascular diseases are the sum of effects from endogenous growth promoters and suppressors. Their characterization of how heparin-like compounds serve as suppressors and heparin-binding growth factors as promoters contributed to the creation of a rigorous framework by which to appreciate how these agents interact with one another in vivo. Additional studies enabled further definition of the nomenclature and kinetics for the FGF-2 receptor complex, characterization of synergy between many growth factors, and demonstration that the mode of growth factor or inhibitor delivery determines biologic effect.

The applied aspects of their work flow from the umbrella of growth modulation. They reasoned that the optimal way to control a biologic event was by recapitulating natural means of regulation. Hence, polymeric controlled drug delivery systems should mimic natural release systems, and vascular implants should be devised with an intimate knowledge of the injury they induce. The development and mathematical characterization of perivascular and stent-based drug delivery is an example of the former, and design of an endovascular stent from first principles is an example of the latter. The basic and applied aspects of his operation are intimately joined. Work with antisense oligonucleotides, HDL receptor biology and tissue engineered endothelial implants are a few examples where these two fields come together in his laboratory. Many of his findings are now in clinical trial validation. Almost 300 students and postdoctoral fellows have passed through Dr. Edelman’s laboratory enabling publications of numerous papers and patents.

Recent Work

  • Video

    9.21.20-Nano.Sense-Day_1-Welcome-Sesson-1: CELL AND SUBCELL

    September 21, 2020Conference Video Duration: 127:34
    Brian Anthony
    Associate Director, MIT.nano
    Faculty Lead, Industry Immersion Program in Mechanical Engineering
    Vladimir Bulovic
    Director, MIT.nano; Fariborz Maseeh (1990) Chair in Emerging Technology; Professor of Electrical Engineering, MacVicar Fellow

    Keynote: MATERIALS, MEDICINE, HEALTH: SENSING THE WORLD AROUND US AT ALL SCALES
    Elazer Edelman
    Director, Institute for Medical Engineering and Science, MIT
    Democratizing Single Molecule Nanoarrays
    Ashwin Gopinath
    Assistant Professor, Mechanical Engineering
    Interferometric Imaging for Studying Sickle Cell Disease and Cancer Metastasis
    Peter So
    Professor, Mechanical Engineering and Biological Engineering
    Dynamic Lens Systems for Biosensing
    Timothy Swager
    John D. MacArthur Professor of Chemistry

    Elazer Edelman

    November 16, 2015MIT Faculty Feature Duration: 17:41

    MIT Professor of Health Sciences & Technology