Building a successful new venture within an existing organization is not easy. Organizations become successful by building optimized, repeatable businesses. Entrepreneurial ventures, on the other hand, require an iterative, experimental mindset, and a completely different set of skills. In this talk, we will explore how leaders can help make their organizations more entrepreneurial via the Disciplined Corporate Entrepreneurship framework. There are three parts to this framework: Strategy, Enablement, and Practice. We will discuss how C-level executives make decisions to invest in innovation, how leaders of innovation labs and initiatives can select and deploy enablement tools, and how corporate entrepreneurs can leverage organizational and entrepreneurial skills to generate net new business value and build successful ventures.