The impetus for the SENSE.nano is the recognition that novel sensors and sensing system are bound to provide previously unimaginable insight into the condition of individuals, as well as built and natural world, to positively impact people, machines, and environment. Advances in nano-sciences and nano-technologies, pursued by many at MIT, now offer unprecedented opportunities to realize designs for, and at-scale manufacturing of, unique sensors and sensing systems, while leveraging data-science and IoT infrastructure.