Manufacturing has advanced enormously over the past century; however, today’s manufacturing technologies cannot support the next generation of advanced products while further fragmenting global supply chains. I will articulate how digital-first production approaches, combining computational design tools with new process technologies, can allow the industry to rethink the architecture of future production systems. I will also introduce the Manufacturing@MIT Initiative, which brings together MIT faculty and students to develop research programs, education and training curricula, and partnerships to accelerate new manufacturing approaches.