Engineering translatable technologies to help global populations, and especially in developing countries has been met with various challenges related to infrastructure, patient access, and cold chain. I will present how polymers can be leveraged with engineering design to develop solutions for global health. For example, the development of the SEAL (StampEd Assembly of polymer Layers) technology that allows controlled pulsatile release of biologics days to months after injection, for single-injection self-boosting vaccines and cancer immunotherapy will be discussed. Additionally, the design of a microneedle vaccine printer that enables decentralized manufacturing of thermostable COVID-19 mRNA vaccine will be presented.