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U.S. manufacturing is at a transformational moment as the country embarks on an ambitious agenda to rebuild its industrial base. Supply chain priorities, climate threats, a changing geopolitical landscape, technological advances, and a new trajectory in public policy are leading to breakthrough innovations and significant investments in domestic manufacturing. Across core industries – transportation, semiconductors, defense, energy, and materials– there is a generational shift in U.S. manufacturing toward greater resilience, digitalization, and sustainability.  Liz Reynolds will provide an overview of the recent changes that are impacting the U.S. industrial base and the implications for U.S. manufacturing going forward.