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The 2025 MIT Japan Conference will explore future research trends at MIT, highlighting breakthroughs in key areas such as Soft Materials and Mechanics, Biomedical Innovation, and the impact of Generative AI (GAI) on the Work of the Future. Additional sessions will focus on Quantum and Silicon Photonics, Nanotechnology in materials and additive manufacturing, and the latest Machine Learning and AI tools for chemical discovery. Advances in semiconductor technology, hydrogen innovation, and electrochemistry, as well as thermofluidic interfaces, will also be featured.