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19219 search results found
  • STEX - 2019 Life Sciences Conference

    December 10, 2019Conference Video Duration: 56:50

    Startup Lightning Talks Part I

    AI/ML
    - Celsius Therapeutics: AI & single cell genomics for autoimmune & immune oncology therapy
    - Javelin Biotech: Complex in vitro models & AI to optimize lead selection
    - Coral Genomics: Scalable functional human genomics for drug development
    - twoXAR: Pharmaceutical company utilizing AI for drug discovery
    - Secure AI Labs: AI security & data privacy to accelerate life science analytics
    - Legit: AI-powered research assistant for life sciences
    - TetraScience: Streamlined R&D lab workflows with data integration
     

    Startup Lightning Talks Part II

    Diagnostics, Peptides, & Synthetic Bio
    - Nirmidas Biotech: IR fluorescence science for molecular diagnostics, in vivo imaging, & therapeutics
    - ConquerX: Multi-biomarker electro-chemical cancer diagnostic
    - Resolute Bio: Discovery platform optimizing peptide therapeutics
    - Mytide: Industrializing peptide manufacturing for iterative drug discovery
    - Cellino: Image-guided, Laser-driven manufacturing of human tissues
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Bernard Munos - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 33:16

    The Future of Drug R&D: How Biomedical Scientists Will Square the Circle

    That will cover both challenges that seem intractable today and advances that offer a pathway towards more innovation, cheaper and faster innovation, as well as a shift from incremental to exponential innovation.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Linda Griffith - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 28:24

    PhysioMimetics: From Organoids to Organs - on - Chips, through Systems Biology

    “Mice are not little people” – a refrain becoming louder as the strengths and weaknesses of animal models of human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell and intracellular signaling networks in patient-derived samples; 3D tissue engineered models of human organ systems, often made from stem cells; and micro-fluidic and meso-fluidic devices that enable living systems to be sustained, perturbed and analyzed for weeks in culture. This talk will highlight the integration of these rapidly moving fields to understand difficult clinical problems, with an emphasis on translating academic discoveries into practical use. Technical challenges in modeling complex diseases with “organs on chips” approaches include the need for relatively large tissue masses and organ-organ cross talk to capture systemic effects, as well as new ways of thinking about scaling to capture multiple different functionalities from drug clearance to cytokine signaling crosstalk. Examples in gynecology, metabolic diseases and other chronic inflammatory conditions will be highlighted.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • J. Christopher Love - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 31:36

    Fast and Modular Manufacturing Systems for Biopharmaceuticals and Vaccines

    Recombinant biopharmaceuticals and vaccines represent a significant class of therapeutics and preventions. While the industry has established efficient platformed processes for the production of monoclonal antibodies at multi-ton scales, the improved precision of therapeutic indications and expanding molecular designs (such as bispecific antibodies, nanobodies, and others) add new challenges for the timely and cost-effective production of emerging therapeutic concepts. This talk will present an integrated approach to biomanufacturing that combines automated end-to-end production and purification along with a fast and engineering-friendly alternative host to enable a flexible platform for next-generation manufacturing. Examples in both biopharmaceuticals and vaccines will be presented.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Andrew W. Lo - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 31:58

    Estimating and Predicting Clinical Trial Success Rates: A Data Science Approach

    All investors require some understanding of the potential risk and reward of a given venture before they’re willing to invest, and the less they know about it, the less capital will be available. This is especially true with biomedical assets in which the risks and rewards are equally outsized and hard to evaluate. Therefore, a prerequisite for addressing the so-called “Valley of Death” in early-stage biomedical R&D funding is better risk analytics. In this talk, Prof. Lo will describe his latest research on estimating historical probabilities of success for clinical trials and then applying machine-learning techniques to predict future success rates across a variety of drug/indication pairs. With more accurate assessments of these success probabilities, capital can be deployed more efficiently and at lower cost, thereby bringing greater amounts of capital into the biopharma industry at a time when capital is needed most.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Klavs Jensen - 2019 Life Science Conference

    December 10, 2019Conference Video Duration: 29:28

    Machine Learning and Process Intensification in Pharmaceutical Development and Continuous Manufacturing

    Machine learning of chemical information is applied to computer aided chemical synthesis - the planning of reaction paths to a given molecular target from purchasable starting materials. The use of robotics with expert user input enable execution of identified reaction paths in an automated modular continuous flow platform. Advances in automated screening and optimization of chemical reactions accelerate translation of laboratory discoveries to manufacturing. Finally, process intensification is illustrated with on-demand synthesis pharmaceuticals in plug-and-play, manually reconfigurable, refrigerator-sized manufacturing platforms.
     
    2019 MIT Increased Productivity in the Biopharmaceutical Industry Conference
  • Eli Paster - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 17:11

    PolyJoule: Stationary Energy Storage: The Epicenter of Renewable Adaptation and the 21st Century Grid

    Stationary energy storage seeks to disrupt the electricity markets on a global scale. Safe, inexpensive energy storage, the missing link in the electricity grid’s 140-year history, will: (1) supplement large capital infrastructure upgrades with low-cost storage; (2) pair with renewables to realize cost effective alternatives to fossil fuel generation; (3) upturn legislative and regulatory restrictions, ushering in digital and energy-sharing economic and societal opportunities.

    PolyJoule has developed a non-lithium form of energy storage that is built purposely for the electricity grid. Safety is molecularly designed into our battery chemistry, streamlining permitting and usability. PolyJoule batteries can respond to both base loads and peak loads in microseconds, allowing the same energy storage system to participate in multiple power markets and deployment use cases. Upfront asset costs are low. Lifetime battery reliability is high. This lecture will introduce PolyJoule, our proprietary energy storage chemistry, its performance profile, and how congested electricity grids, renewable adaptation, and environmental tidal waves all benefit from low-cost, high-power energy storage assets.

    2019 MIT Madrid Symposium
  • Marshall Chapin - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 30:19

    Indigo Technologies: In-wheel motors - the key to unlocking tomorrow's mobility

    Technology is changing the world at a blistering pace, and established industries are being rapidly displaced, often in a matter of years. Airbnb, Uber, Netflix, Spotify - all multi-billion dollar businesses which unseated highly entrenched incumbents. Nowhere is this more evident than the transportation sector, and the highly integrated and coordinated automotive industry.

    The automotive industry is telling the world that it's reinventing itself too, but the supposedly groundbreaking new vehicles they offer are largely built on the same century-old vehicle designs. Global need for immediate order-of-magnitude improvements in vehicle efficiency combined with a rise in mobility-as-a-service preferences and autonomous systems mean the traditional incremental change in vehicle design will not be sufficient for auto makers to remain competitive.

    Indigo Technologies is working to break this vehicle design paradigm. The vehicles of tomorrow need to be highly efficient, lightweight, modular, and flexible, using advanced manufacturing techniques and materials. Indigo unlocks this future with its core technology, an innovative in-wheel motor with integrated active suspension, which frees vehicle designers from the constraints of encapsulating a traditional powertrain and allows for efficient design. Marshall will explain how this technology, as well as Indigo's wireless power transfer system, is helping forward-thinking OEMs design and build the future of mobility.

    2019 MIT Madrid Symposium
  • Round Table - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 47:0

    Roundtable Discussion

    2019 MIT Madrid Symposium
  • Patrick Anquetil - 2019 Madrid Video

    November 7, 2019Conference Video Duration: 32:8

    Portal Instruments: Medical Injections Transformed with Connected Needle-free Technology

    The adherence to treatment in injectable therapies for chronic diseases (e.g. rheumatoid arthritis, multiple sclerosis, psoriasis, Crohn’s disease, etc.) is extremely low (45% - 60%) and in part due to the inconvenience and anxiety associated with using needles and syringes. Biological medicines treating those conditions cannot be formulated as pills and as such there is a huge opportunity for new technologies replacing needles and syringes to transform the perception, approachability and market penetration of such therapies. Portal has developed a next-generation needle-free drug delivery platform that is computer-controlled, easy to use and patient preferred. Real time injection tracking via cloud-based connectivity enables patients and their care teams to manage their condition better and take charge of their wellbeing. Issued from Professor Ian Hunter’s research at the MIT BioInstrumentation Lab, this technology leverages advances in multiple disciplines such as high-power density electromagnetic actuators, ARM-based micro-electronics and embedded software, and energy storage. The company is at the commercial stage, preparing to launch a drug/device combination product with Takeda Pharmaceuticals in the field of Inflammatory Bowel Diseases. A live demonstration of the Portal Device will be presented at the Symposium.

    2019 MIT Madrid Symposium

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