Principal Investigator Paula Hammond
Project Website http://web.mit.edu/hammond/lab/seungwoo.htm
By leveraging biomaterials chemistry, we aim to design innovative approaches for controlling hemostasis, enhancing wound healing, and developing artificial oxygen-carrier. The Hammond Lab has developed interactive two-component systems, consisting of targeting and crosslinking components, for the treatment of internal bleeding by amplifying platelet recruitment and mitigating plasminolysis for greater clot stability. This work addresses the need for supplementation of the native hemostasis process and provides guiding principles for future development of artificial blood replacement. To improve translatability of our technology, we are further investigating hemoglobin-based oxygen carriers amenable to freeze-drying and long-term storage.