Prof. George M Church

The mission of our group is to develop easily distributed, integrated models for biomedical and ecological systems. To make these systems-biology models useful and accurate, we develop biotechnologies suitable for comprehensive yet cost-effective systems measures and synthesis of designed biosystems. In particular: (1) $1000 human genome & phenome technology & interpretation software. (2) Cancer genomics -- somatic mutation, drug resistance, splicing. (3) Immune cell signaling & interplay of T-cell HLA & HIV-gag variation. (4) Photosynthetic ecosystem genomic, RNA, mass-spec-proteomic measures, & models. (5) Synthetic genomes, new translational codes for resistance to all viruses. (6) Engineering stem cell epigenetics for lowered cancer & senescence. (7) Design of 3D biological structures & mirror-chirality. (8) Interaction of metabolic & RNA regulatory systems. (9) Imaging of RNAi effects on cell morphology. (10) Detailed 4D models of genome folding and replication.

Professor Church also is director of the MIT/Harvard DOE-sponsored “Genomes to Life” center, an interdisciplinary program that is investigating comprehensive systems view of microbial protein-complexes and regulation in complex environmental communities. His laboratory is collaborating on computer modeling and technology development and integration and dedicated to community shareable models and data.