4.12.22-Health-Science-Eric-Smith

• Video details

  CAR T cell therapies for relapsed/refractory hematologic malignancies induce frequent deep clinical responses in patients who failed all other treatment options. While these results are game changing, the field is only scratching the surface of the potential benefit gene and cell therapies can provide.  Future advances include discovery of novel target antigens, extension of CAR T cell clinical benefit to solid tumors, logic gated engineering designs, advances in manufacturing, targeted in situ gene delivery, and off-the-shelf immunologically stealth approaches. The above will be broadly addressed and work from our group developing and translating CAR T cell therapies targeting the novel antigen GPRC5D for myeloma and “OR” gating strategies for hematologic malignancies will be highlighted as examples.

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