These multifunctional elements can be exemplified by the emerging architectured metamaterials with integrated functions that are desirable for a broad array of applications in confined spaces, including impact absorption, thermal management and chemical processing, optical transparency, structural morphing, as well as real time monitoring and repair. The control of spatial arrangements with functional printable materials determines the mass transport and energy transfer within architected microreactors, which are significant for many emerging applications, including use in catalytic, biological, battery, or photochemical reactors. In this talk we shall review the state-of-the-art of research in the development of some of the most advanced digital manufactured functional microreactors. We then the outline major challenges in the field and provide our perspectives on future research and development directions.