Principal Investigator Salil Garg
Project Website http://garg-lab.mit.edu/
Project Start Date July 2020
The Garg lab is interested in the processes that generate heterogeneity in tumors and development. We investigate the structures of genes and networks to understand how they contribute to variation and treatment failure in cancer.
The Lab confronts cancer with an ever expanding array of drugs, and yet it keeps coming back. Recurrent disease can be caused by mutation but many times the cause of treatment failure is more mysterious. The hypothesis is that mammalian cells contain gene programs that naturally give rise to variation within a population and that cancer exploits these gene network structures in recurrent disease. We test this idea with a combination of cell biology, genomics, bioinformatics, and technology development.