Deep Generative Models for Cryo-EM Reconstruction of Heterogeneous Biomolecular Structures

In this project we propose to develop revolutionary machine learning based techniques to determine structural ensembles of “misfolded” complexes. This work leverages the Berger Lab’s expertise in such computational approaches, MIT’s recent investments in cryo-EM instrumentation (MIT.nano), and Davis Lab’s expertise in producing, isolating and imaging such molecules.