The impact of energy production in our lives stands in stark contrast to the speed, or lack thereof, in solving the most expensive and pervasive issues in energy production. Examples range from the continuing prevalence of fouling, which drains 0.25% of the GDP of developed countries, to the lack of ways to quantify damage to materials. The Mesoscale Nuclear Materials group at MIT (MIT-MNM) focuses on science-based solutions to these "dirty issues," combining branches of physics and engineering to produce industry-ready solutions in years, not decades. We will focus on three issues facing the nuclear industry as well as others: (1) The formation and prevention of CRUD in reactors, (2) rapid qualification of new materials during irradiation, and (3) the stored energy fingerprints of radiation damage as a new way to quantify damage to materials.