Principal Investigator Michael Birnbaum
Project Website http://birnbaum-lab.mit.edu/research/topic4
In addition to their roles in the immune system, peptide-MHCs and their receptors have been shown to profoundly affect neural connectivity and function. However, what role the presented peptides play in this function, and whether different MHC alleles differentially affect activity, are unknown. We are studying these interactions to create tools that will allow us to decouple the various roles of immune receptors in neuronal function.