Principal Investigator Gabriela Schlau-Cohen
Project Website http://www.schlaucohenlab.com/singlemolecule-spectroscopy/
Single-molecule spectroscopy goes beyond ensemble-averaged information to uncover asynchronous behavior and heterogeneity, characteristics intrinsic to biological systems. We employ and develop single-molecule methods to explore dynamics. Single-molecule Förster resonance energy transfer (smFRET) enables the study of important structural dynamics under physiological conditions. These single-molecule experiments allow us to investigate a wide variety of systems ranging from biological receptors to natural and artificial light harvesting systems. Our lab is also developing an ultrafast single-molecule experiment to study heterogeneity in energy transfer dynamics in photosynthetic systems.