Entry Date:
October 15, 2015

Exploring the Therapeutic Potential of Small Molecules that Modulate the c-Myc Oncoprotein


Controlling the function of overactive transcription factors is an emerging therapeutic strategy in oncology. The team has identified compounds that bind to protein complexes containing the prolific oncoprotein c-Myc and found a subset that modulate Myc-driven functions in cells, including Myc-mediated transcription. They will explore the therapeutic potential of Myc modulation.