Principal Investigator Angela Koehler
Project Website http://deshpande.mit.edu/portfolio/project/exploring-therapeutic-potential-smal…
Controlling the function of overactive transcription factors is an emerging therapeutic strategy in oncology. The team has identified compounds that bind to protein complexes containing the prolific oncoprotein c-Myc and found a subset that modulate Myc-driven functions in cells, including Myc-mediated transcription. They will explore the therapeutic potential of Myc modulation.