Principal Investigator Stephen Buchwald
Co-investigators Brad Pentelute , Timothy Swager , Chi Zhang
Project Website http://deshpande.mit.edu/portfolio/project/novel-approaches-antibody-drug-conju…
Antibody-Drug Conjugates (ADCs) for cancer therapy are synthesized by attaching cytotoxic small molecule drugs to monoclonal antibodies, using chemical linkers. The team is developing novel linkers to attach the drugs to antibodies. These linkers should allow for a much more effective cancer therapy.