Principal Investigator Gene-Wei Li
The ability to precisely measure the rate of protein production and proteome composition gives us a unprecedented opportunity to start understanding cell biology at a quantitative level. In particular, we are interested in how the production of a given protein is connected to the physiology of the entire cell. We use bacteria and yeast as model systems to discover the rationales for protein expression levels. Our goal is to establish a quantitative framework for addressing this question, which can be translated into human diseases where a twofold change in protein expression can have devastating effects.